; Biotech Research and Innovation Centre, University of Copenhagen
Anders H. Lund graduated from the University of Aarhus, Denmark, in 1996. He trained as a postdoc at the University of Aarhus (1996-1999) and the Netherlands Cancer Institute (1999-2004) where he worked on the identification of novel oncogenes. He was appointed associate professor at the Biotech Research and Innovation Centre (BRIC), University of Copenhagen in 2004, became full professor in 2009, and was appointed Director of BRIC in 2019. With a focus on RNA modifications, translation and specialized ribosomes, the aim of the laboratory is to unveil fundamental biological mechanisms and understand how these become perturbed during diseases.
Protein synthesis is essential for all cellular processes, and it is pivotal to understand how protein synthesis is regulated to facilitate differentiation and establish cellular identity. Importantly, the translation system is deregulated or hijacked in many diseases and understanding how deregulated protein synthesis contributes to the development of disease may facilitate new therapeutic approaches. In this seminar, examples of disease-mediated changes to protein synthesis will be discussed with a focus on colorectal cancer. Furthermore, early attempts to develop compounds capable of targeting specific disease-related ribosome subtypes presented.
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